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Effect of antioxidant vitamin supplementation on endothelial function in type 2 diabetes mellitus: a systematic review and meta‐analysis of randomized controlled trials
Author(s) -
Montero D.,
Walther G.,
Stehouwer C. D. A.,
Houben A. J. H. M.,
Beckman J. A.,
Vinet A.
Publication year - 2014
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/obr.12114
Subject(s) - medicine , randomized controlled trial , vitamin e , antioxidant , meta analysis , endothelial dysfunction , body mass index , type 2 diabetes , type 2 diabetes mellitus , diabetes mellitus , confidence interval , vitamin , gastroenterology , endocrinology , biology , biochemistry
Summary Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type 2 diabetes mellitus ( T2DM ) subjects. The aim of this study was to systematically review and quantify the effect of antioxidant vitamin supplementation on endothelial function in T2DM subjects. MEDLINE , C ochrane, S copus and W eb of S cience were searched up to F ebruary 2013 for randomized controlled trials assessing the effect of antioxidant vitamin E and/or C supplementation on endothelial function in T2DM subjects. Ten randomized controlled trials comparing antioxidant vitamin‐supplemented and control groups (overall n = 296) met the inclusion criteria. Post‐intervention standardized mean difference ( SMD ) in endothelial function did not reach statistical significance between groups (0.35; 95% confidence interval = −0.17, 0.88; P = 0.18). In subgroup analysis, post‐intervention endothelial function was significantly improved by antioxidant vitamin supplementation in T2DM subgroups with body mass index ( BMI ) ≤ 29.45 kg m −2 ( SMD = 1.02; P < 0.05), but not in T2DM subgroups with BMI > 29.45 kg m −2 ( SMD = −0.07; P = 0.70). In meta‐regression, an inverse association was found between BMI and post‐intervention SMD in endothelial function ( B = −0.024, P = 0.02). Prolonged antioxidant vitamin E and/or C supplementation could be effective to improve endothelial function in non‐obese T2DM subjects.