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The role of nesfatin‐1 in the regulation of food intake and body weight: recent developments and future endeavors
Author(s) -
Stengel A.,
Mori M.,
Taché Y.
Publication year - 2013
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/obr.12063
Subject(s) - leptin , endocrinology , medicine , food intake , hormone , obesity , body weight , ghrelin , endocrine system , glucose homeostasis , biology , homeostasis , neuropeptide y receptor , neuropeptide , receptor , insulin resistance
Summary Nesfatin‐1 was discovered in 2006 and introduced as a potential novel anorexigenic modulator of food intake and body weight. The past years have witnessed increasing evidence establishing nesfatin‐1 as a potent physiological inhibitor of food intake and body weight and unravelled nesfatin‐1's interaction with other brain transmitters to exert its food consumption inhibitory effect. As observed for other anorexigenic brain neuropeptides, nesfatin‐1 is also likely to exert additional, if not pleiotropic, actions in the brain and periphery. Recent studies established the prominent expression of the nesfatin‐1 precursor, nucleobindin2 ( NUCB 2), in the stomach and pancreas, where nesfatin‐1 influences endocrine secretion. This review will highlight the current experimental state‐of‐knowledge on the effects of NUCB 2/nesfatin‐1 on food intake, body weight and glucose homeostasis. Potential implications in human obesity will be discussed in relation to the evidence of changes in circulating levels of NUCB 2/nesfatin‐1 in disease states, the occurrence of genetic NUCB 2 polymorphisms and – in contrast to several other hormones – the independence of leptin signalling known to be blunted under conditions of chronically increased body weight.