Fat‐resident  T regs: an emerging guard protecting from obesity‐associated metabolic disorders | Zendy

Chen X. | Zendy; Wu Y. | Zendy; Wang L. | Zendy

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Fat‐resident T regs: an emerging guard protecting from obesity‐associated metabolic disorders

Author(s) -

Chen X.,

Wu Y.,

Wang L.

Publication year - 2013

Publication title -

obesity reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.845

H-Index - 162

eISSN - 1467-789X

pISSN - 1467-7881

DOI - 10.1111/obr.12033

Subject(s) - adipose tissue , obesity , foxp3 , inflammation , medicine , immune system , insulin resistance , regulator , regulatory t cell , type 2 diabetes , disease , immunology , diabetes mellitus , metabolic syndrome , t cell , endocrinology , biology , il 2 receptor , biochemistry , gene

Summary Obesity, a chronic, low‐grade inflammatory disease, is associated with alterations of multiple immune‐cell components in the visceral adipose tissue ( VAT ), in which CD 4 + F oxp3 + regulatory T cells ( Tregs ) have been suggested to be a critical regulator. This review focuses on the current understanding of VAT ‐resident T regs ( VAT T regs) and their intriguing roles in modulating fat tissue inflammation and obesity‐associated metabolic disorders. The potential mechanisms for the regulation of VAT T regs in lean vs. obese individuals are also discussed. Accumulating evidence reveals that the modulation of VAT T regs may offer a potential novel strategy for treating obesity‐related metabolic disorders, such as insulin resistance and type 2 diabetes.

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