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Rethinking gastroesophageal reflux disorder
Author(s) -
Banting Samuel P.,
Badgery Henry E.,
Read Matthew,
Mashimo Hiroshi
Publication year - 2020
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.14478
Subject(s) - gerd , disease , therapeutic modalities , psychological intervention , intervention (counseling) , mechanism (biology) , intensive care medicine , reflux , medicine , modalities , pathophysiology , bioinformatics , pathology , psychiatry , biology , social science , philosophy , epistemology , sociology
Gastroesophageal reflux disease (GERD) is a common clinical condition for which our understanding has evolved over the past decades. It is now considered a cluster of phenotypes with numerous anatomical and physiological abnormalities contributing to its pathophysiology. As such, it is important to first understand the underlying mechanism of the disease process for each patient before embarking on therapeutic interventions. The aim of our paper is to highlight the mechanisms contributing to GERD and review investigations and interpretation of these results. Finally, the paper reviews the available treatment modalities for this condition, ranging from medical intervention, endoscopic options through to surgery and its various techniques.