Premium
Eosinophilic esophagitis: updates on key unanswered questions
Author(s) -
FernandezBecker Nielsen Q.,
Raja Shreya,
Scarpignato Carmelo,
Lynch Kristle L.,
Ahuja Nitin K.,
HorsleySilva Jennifer L.
Publication year - 2020
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.14421
Subject(s) - eosinophilic esophagitis , dysphagia , eosinophilia , medicine , esophagitis , immune dysfunction , esophagus , disease , pathophysiology , esophageal disorder , fibrosis , inflammation , immune system , immunology , gastroenterology , pathology , reflux , surgery
Eosinophilic esophagitis (EoE) is a clinicopathologic disease characterized by symptoms of esophageal dysfunction and esophageal eosinophilia. In the last decade, there has been a dramatic increase in its prevalence for reasons that are not completely understood. The underlying pathophysiology involves an antigen‐mediated T H 2 immune response that draws eosinophils to the esophagus, causing mucosal inflammation, esophageal remodeling, and fibrosis. This ultimately leads to esophageal dysfunction that most commonly manifests as dysphagia. In this review, we will discuss updates on key questions regarding the diagnosis and treatment of EoE.