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Relationships between objective sleep parameters and inflammatory biomarkers in pregnancy
Author(s) -
Zhu Bingqian,
Bronas Ulf G.,
Carley David W.,
Lee Kathryn,
Steffen Alana,
Kapella Mary C.,
IzciBalserak Bilgay
Publication year - 2020
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.14375
Subject(s) - morning , bedtime , polysomnography , sleep (system call) , medicine , evening , pregnancy , sleep stages , endocrinology , biology , physics , apnea , astronomy , computer science , genetics , operating system
We examined the relationships between sleep and inflammatory biomarkers during late pregnancy. Seventy‐four women underwent an overnight sleep assessment by polysomnography. Blood samples were collected before bedtime and again within 1 h upon awakening to measure C‐reactive protein (CRP), interleukin (IL)‐6, and IL‐6 soluble receptor. Sleep parameters included variables characterizing sleep architecture and sleep continuity. The participants were 32.2 (SD = 4.1) years old, and the average gestational age was 32.8 (3.5) weeks. Controlling for covariates, evening CRP was negatively associated with N3 sleep (β = −0.30, P = 0.010). N3 sleep was also negatively associated with morning CRP (β = −0.26, P = 0.036), with a higher percentage of N3 sleep associated with a lower level of morning CRP. Contrarily, there was a tendency for a positive association between stage N2 sleep and morning CRP (β = 0.23, P = 0.065). Stage N1 sleep was associated with morning IL‐6 (β = 0.28, P = 0.021), with a higher percentage of N1 sleep associated with a higher morning IL‐6. No significant associations were found between morning inflammatory biomarkers and sleep continuity parameters. In conclusion, increased light sleep was associated with increased inflammatory biomarkers, whereas more deep sleep was associated with decreased inflammatory biomarkers. These findings further support the interactions between sleep and the immune system during late pregnancy.