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Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations
Author(s) -
Klimara Miles J.,
Randall Derrick R.,
Allen Jacqueline,
Figueredo Edgar,
Johnston Nikki
Publication year - 2020
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.14366
Subject(s) - reflux , airway , medicine , disease , intervention (counseling) , pathophysiology , intensive care medicine , pathology , surgery , psychiatry
Abstract Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric upper and lower airway diseases. However, the diagnosis of proximal reflux–associated disease remains challenging due to evolving clinical criteria and institutional and regional variances in diagnostic practices. Evidence suggests that nonacidic contents of reflux may serve as both pathologic mediators of and biomarkers for reflux in the upper airway. Furthermore, they offer potential pharmaceutical and surgical intervention targets and are the focus of novel clinical diagnostic tools currently under investigation.