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Creative targeting of the Gram‐negative outer membrane in antibiotic discovery
Author(s) -
MacNair Craig R.,
Tsai Caressa N.,
Brown Eric D.
Publication year - 2020
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.14280
Subject(s) - bacterial outer membrane , antibiotics , antimicrobial , drug discovery , gram negative bacteria , membrane permeability , bacteria , biology , microbiology and biotechnology , antimicrobial drug , multiple drug resistance , membrane , bioinformatics , biochemistry , escherichia coli , genetics , gene
The rising threat of multidrug‐resistant Gram‐negative bacteria is exacerbated by the scarcity of new antibiotics in the development pipeline. Permeability through the outer membrane remains one of the leading hurdles in discovery efforts. However, the essentiality of a robust outer membrane makes itself an intriguing antimicrobial target. Herein, we review drug discovery efforts targeting the outer membrane and the prospective antimicrobial leads identified.