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Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta‐analysis
Author(s) -
Asis Marzieh,
Hemmati Niloufar,
Moradi Sajjad,
Nagulapalli Venkata Kalyan C.,
Mohammadi Elham,
Farzaei Mohammad Hosein,
Bishayee Anupam
Publication year - 2019
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.14226
Subject(s) - resveratrol , n terminal telopeptide , meta analysis , alkaline phosphatase , medicine , placebo , randomized controlled trial , bone remodeling , osteocalcin , bone health , endocrinology , gastroenterology , pharmacology , osteoporosis , chemistry , bone mineral , biochemistry , pathology , enzyme , alternative medicine
Abstract The current study presents a comprehensive systematic review and meta‐analysis of randomized controlled trials (RCTs) on resveratrol and bone health biomarkers. PubMed, Scopus, and Web of Science (until September 2018) were searched to identify the potential RCTs with information on resveratrol supplementation and bone metabolism biomarkers. Mean differences (MD) were analyzed using a random‐effects model. Pooling six RCTs (eight treatment arms with 264 subjects) together identified no significant reduction of serum Ca, osteocalcin, C‐terminal telopeptide of type I collagen, and procollagen I N‐terminal propeptide values after resveratrol supplementation over placebo treatment. However, a significant increase in serum alkaline phosphatase (ALP) (MD: 5.69 mg/mL, 95% CI: 3.58–7.80, I 2 = 95.7%, P < 0.001) and bone alkaline phosphatase (BAP) (MD: 10.57 mmHg, 95% CI: 5.36–15.78, I 2 = 99.2%, P < 0.001) values was observed after resveratrol treatment relative to placebo. The findings of this study indicate that resveratrol supplementation increased some key bone biomarkers, such as ALP and BAP. Further precise clinical trials of the effects of resveratrol supplementation on bone health should be conducted.