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Plasmid evolution in carbapenemase‐producing Enterobacteriaceae : a review
Author(s) -
Kopotsa Katlego,
Osei Sekyere John,
Mbelle tombi Marylucy
Publication year - 2019
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.14223
Subject(s) - plasmid , replicon , biology , enterobacteriaceae , typing , microbiology and biotechnology , antibiotic resistance , carbapenem , gene , genetics , antibiotics , escherichia coli
Carbapenem‐resistant Enterobacteriaceae (CRE) have been listed by the WHO as high‐priority pathogens owing to their high association with mortalities and morbidities. Resistance to multiple β‐lactams complicates effective clinical management of CRE infections. Using plasmid typing methods, a wide distribution of plasmid replicon groups has been reported in CREs around the world, including IncF, N, X, A/C, L/M, R, P, H, I, and W. We performed a literature search for English research papers, published between 2013 and 2018, reporting on plasmid‐mediated carbapenem resistance. A rise in both carbapenemase types and associated plasmid replicon groups was seen, with China, Canada, and the United States recording a higher increase than other countries. bla KPC was the most prevalent, except in Angola and the Czech Republic, where OXA‐181 ( n = 50, 88%) and OXA‐48–like ( n = 24, 44%) carbapenemases were most prevalent, respectively; bla KPC‐2/3 accounted for 70% ( n = 956) of all reported carbapenemases. IncF plasmids were found to be responsible for disseminating different antibiotic resistance genes worldwide, accounting for almost 40% ( n = 254) of plasmid‐borne carbapenemases. bla CTX‐M , bla TEM , bla SHV , bla OXA‐1/9 , qnr , and aac‐(6′)‐lb were mostly detected concurrently with carbapenemases. Most reported plasmids were conjugative but not present in multiple countries or species, suggesting limited interspecies and interboundary transmission of a common plasmid. A major limitation to effective characterization of plasmid evolution was the use of PCR‐based instead of whole‐plasmid sequencing–based plasmid typing.