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Caloric restriction combined with exercise is effective in reducing adiposity and mitigating bone structural deterioration in obese rats
Author(s) -
Cao Jay J.
Publication year - 2018
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13936
Subject(s) - endocrinology , medicine , osteocalcin , bone remodeling , bone mineral , caloric theory , chemistry , alkaline phosphatase , osteoporosis , biochemistry , enzyme
Weight reduction through caloric restriction (CR) or exercise can have opposite effects on bone. This study investigated the effects of comparable weight reduction through CR and/or exercise on body composition and bone structure in an obese rat model. Male 6‐week‐old rats were fed either a normal‐fat diet for 6 months or a high‐fat (HF) diet for 3 months and then started on different CR or exercise regimens for an additional 3 months. Compared to HF conditions, rats given HF diet plus CR at 8% (HF+8CR), HF diet plus CR at 16% (HF+16CR), or HF+8CR plus exercise (HF+Ex+8CR) had lower fat mass. In addition, HF+8CR rats had lower serum tartrate‐resistant acid phosphatase and bone volume/total volume at distal femur ( P < 0.05), and HF+16CR rats had lower serum insulin growth factor 1, osteocalcin, tartrate‐resistant acid phosphatase, and bone volume/total volume at distal femur and 2nd lumbar vertebrae, compared to regimens that included exercise. These data indicate that while CR (e.g., HF+8CR) was detrimental to bone structure, combined with exercise CR (e.g., HF+Ex+8CR) was effective in decreasing adiposity and mitigating bone structural deterioration associated with weight reduction in obese rats.