Premium
Acetylcholine receptor antibody–mediated animal models of myasthenia gravis and the role of complement
Author(s) -
Kusner Linda L.,
Sengupta Manjistha,
Kaminski Henry J.
Publication year - 2018
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13555
Subject(s) - myasthenia gravis , complement (music) , acetylcholine receptor , medicine , immunology , acetylcholine , disease , antibody , complement system , neuroscience , receptor , biology , pharmacology , biochemistry , complementation , gene , phenotype
Because of the failure of many promising therapeutics identified in preclinical evaluation, funding sources have established guidelines for increased rigor in animal evaluations. The myasthenia gravis (MG) community of scientists has developed guidelines for preclinical assessment for potential MG treatments. Here, we provide a focused summary of these recommendations and the role of complement in disease development in experimental models of MG.