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Investigating metabolic regulation using targeted neuromodulation
Author(s) -
Devarakonda Kavya,
Stanley Sarah
Publication year - 2018
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13468
Subject(s) - optogenetics , neuromodulation , neuroscience , central nervous system , neural activity , biological neural network , biology , energy metabolism , neural system , endocrinology
The central nervous system (CNS) plays a vital role in regulating energy balance and metabolism. Over the last 50 years, studies in animal models have allowed us to identify critical CNS regions involved in these processes and even crucial cell populations. Now, techniques for genetically and anatomically targeted manipulation of specific neural populations using light (optogenetic), ligands (chemogenetic), or magnetic fields (radiogenetic/magnetogenetic) allow detailed investigation of circuits involved in metabolic regulation. In this review, we provide a brief overview of recent studies using light‐ and magnetic field–regulated neural activity to investigate the neural circuits contributing to metabolic control.