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The grapes and wrath: using resveratrol to treat the pathophysiology of hemorrhagic shock
Author(s) -
Sims Carrie A.,
Baur Joseph A.
Publication year - 2017
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13444
Subject(s) - resveratrol , oxidative stress , resuscitation , ischemia , inflammation , medicine , shock (circulatory) , hemorrhagic shock , reperfusion injury , perfusion , pharmacology , pathophysiology , sirtuin 1 , sirtuin , hypoxia (environmental) , anesthesia , immunology , cardiology , biology , chemistry , biochemistry , oxygen , downregulation and upregulation , organic chemistry , acetylation , gene
Resveratrol, a naturally occurring polyphenol found in grapes, has been shown to reduce oxidative stress and inflammation in a variety of conditions. Recently, resveratrol has been investigated as a potential adjunct to resuscitation therapy for hemorrhagic shock—a condition characterized by tissue hypoxia, mitochondrial dysfunction, and inflammation. Although standard resuscitation restores tissue perfusion, it can exacerbate oxidative stress and organ damage. In rodent models of severe hemorrhagic shock, resveratrol mitigates reperfusion injury, preserves organ function, and improves survival. While many of these benefits can be attributed to its ability to activate sirtuin 1, resveratrol interacts with many targets that are relevant to ischemia–reperfusion. Here, we explore the probable mechanisms, potential benefits, and possible problems associated with administering resveratrol as an adjunct during resuscitation of hemorrhagic shock.