Premium
Preparation‐related structural diversity and medical potential in the treatment of diabetes mellitus with ginseng pectins
Author(s) -
Chen Qilei,
Zhu Lin,
Tang Yina,
Zhao Zhongzhen,
Yi Tao,
Chen Hubiao
Publication year - 2017
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13424
Subject(s) - ginseng , pectin , arabinogalactan , chemistry , diabetes mellitus , polysaccharide , biochemistry , pharmacology , medicine , endocrinology , pathology , alternative medicine
Pectins isolated from Panax ginseng C.A. Meyer are potential therapeutic agents for the treatment of diabetes mellitus, a global health challenge. Soil‐to‐bench procedures of ginseng pectin preparation significantly affect the polysaccharide structures. Various forms of ginseng pectins rich in homogalacturonan, rhamnogalacturonan‐I, rhamnogalacturonan‐II, and arabinogalactan have demonstrated independent or collaborative effects on hyperglycemia, oxidative stress, immunological dysfunction, and neoplasms. Monosaccharide compositions, peptide contents, degrees of esterification and methylation, and inter‐ and intramolecular linkages all influence pectin bioactivity. Understanding the preparation–structure and structure–function relationships of ginseng pectins can lead to safer and more pertinent treatment of diabetes with efficacy‐oriented modifications of the pectins. To reach this goal, standardization of preparation procedures, understanding of intricate structures, and exploration of complex interactions with receptors are crucial steps to take full advantage of the medical potential of ginseng pectins.