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Modulation of epithelial cell polarity by bacterial pathogens
Author(s) -
Tapia Rocio,
Kralicek Sarah E.,
Hecht Gail A.
Publication year - 2017
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13388
Subject(s) - polarity (international relations) , cell polarity , microbiology and biotechnology , epithelial polarity , tight junction , intracellular , epithelium , cell junction , apical membrane , cell , cell membrane , biology , barrier function , chemistry , biophysics , biochemistry , genetics
Epithelial cells constitute a physical barrier that aids in protecting the host from microbial pathogens. Polarized epithelial cells contain distinct apical and basolateral membrane domains separated by intercellular junctions, including tight junctions (TJs), which contribute to the maintenance of apical–basal polarity. Polarity complexes also contribute to the establishment of TJ formation. Several pathogens perturb epithelial TJ barrier function and structure in addition to causing a loss of apical–basal polarity. Here, we review the impact of pathogenic bacteria on the disruption of cell–cell junctions and epithelial polarity.