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Endocytosis of tight junction proteins and the regulation of degradation and recycling
Author(s) -
Stamatovic Svetlana M.,
Johnson Allison M.,
Sladojevic Nikola,
Keep Richard F.,
Andjelkovic Anuska V.
Publication year - 2017
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13346
Subject(s) - endocytosis , microbiology and biotechnology , endosome , internalization , tight junction , exocytosis , vesicular transport protein , biology , chemistry , cell , vesicle , membrane , biochemistry , intracellular
Internalization of tight junction (TJ) proteins from the plasma membrane is a pivotal mechanism regulating TJ plasticity and function in both epithelial and endothelial barrier tissues. Once internalized, the TJ proteins enter complex vesicular machinery, where further trafficking is directly dependent on the initiating stimulus and downstream signaling pathways that regulate the sorting and destiny of TJ proteins, as well as on cell and barrier responses. The destiny of internalized TJ proteins is recycling to the plasma membrane or sorting to late endosomes and degradation. This review highlights recent advances in our knowledge of endocytosis and vesicular trafficking of TJ proteins in both epithelial and endothelial cells. A greater understanding of these processes may allow for the development of methods to modulate barrier permeability for drug delivery or prevent barrier dysfunction in disease states.