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Resistance diagnosis and the changing epidemiology of antibiotic resistance
Author(s) -
McAdams David
Publication year - 2017
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13300
Subject(s) - antibiotics , antibiotic resistance , context (archaeology) , intensive care medicine , resistance (ecology) , epidemiology , population , medicine , biology , microbiology and biotechnology , environmental health , ecology , paleontology
Widespread adoption of point‐of‐care resistance diagnostics (POCRD) reduces ineffective antibiotic use but could increase overall antibiotic use. Indeed, in the context of a standard susceptible‐infected epidemiological model with a single antibiotic, POCRD accelerates the rise of resistance in the disease‐causing bacterial population. When multiple antibiotics are available, however, POCRD may slow the rise of resistance even as more patients receive antibiotic treatment, belying the conventional wisdom that antibiotics are “exhaustible resources” whose increased use necessarily promotes the rise of resistance.