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Application of genomic technologies to measure and monitor antibiotic resistance in animals
Author(s) -
Su JianQiang,
Cui Li,
Chen QingLin,
An XinLi,
Zhu YongGuan
Publication year - 2017
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13296
Subject(s) - antibiotic resistance , metagenomics , antibiotics , context (archaeology) , biology , genomics , bacteria , resistance (ecology) , gene , computational biology , microbiology and biotechnology , genetics , genome , ecology , paleontology
One of the richest reservoirs of antibiotic‐resistant bacteria and genes, animal intestinal microbiota contributes to the spread of antibiotic resistance in the environment and, potentially, to human pathogens. Both culture‐based genomic technology and culture‐independent metagenomics have been developed to investigate the abundance and diversity of antibiotic resistance genes. The characteristics, strengths, limitations, and challenges of these genomic approaches are discussed in this review in the context of antibiotic resistance in animals. We also discuss the advances in single‐cell genomics and its potential for surveillance of antibiotic resistance in animals.