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The role of progranulin in arthritis
Author(s) -
Wei Jianlu,
Hettinghouse Aubryanna,
Liu Chuanju
Publication year - 2016
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13191
Subject(s) - inflammation , arthritis , osteoarthritis , tumor necrosis factor alpha , medicine , carcinogenesis , bioinformatics , inflammatory arthritis , cancer research , immunology , cancer , biology , pathology , alternative medicine
Progranulin (PGRN) is a growth factor with a unique beads‐on‐a‐string structure that is involved in multiple pathophysiological processes, including anti‐inflammation, tissue repair, wound healing, neurodegenerative diseases, and tumorigenesis. This review presents up‐to‐date information concerning recent studies on the role of PGRN in inflammatory arthritis and osteoarthritis, with a special focus on the involvement of the interactions and interplay between PGRN and tumor necrosis factor receptor (TNFR) family members in regulating such musculoskeletal diseases. In addition, this paper highlights the applications of atsttrin, an engineered protein comprising three TNFR‐binding fragments of PGRN, as a promising intervention in treating arthritis.