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Circadian rhythms and metabolism: from the brain to the gut and back again
Author(s) -
Cribbet Matthew R.,
Logan Ryan W.,
Edwards Mathew D.,
Hanlon Erin,
Bien Peek Clara,
Stubblefield Jeremy J.,
Vasudevan Sridhar,
Ritchey Fiona,
Frank Ellen
Publication year - 2016
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13188
Subject(s) - circadian rhythm , context (archaeology) , neuroscience , translational research , biology , dark therapy , microbiology and biotechnology , paleontology
This paper focuses on the relationship between the circadian system and glucose metabolism. Research across the translational spectrum confirms the importance of the circadian system for glucose metabolism and offers promising clues as to when and why these systems go awry. In particular, basic research has started to clarify the molecular and genetic mechanisms through which the circadian system regulates metabolism. The study of human behavior, especially in the context of psychiatric disorders, such as bipolar disorder and major depression, forces us to see how inextricably linked mental health and metabolic health are. We also emphasize the remarkable opportunities for advancing circadian science through big data and advanced analytics. Advances in circadian research have translated into environmental and pharmacological interventions with tremendous therapeutic potential.