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Multi‐inhibitor prodrug constructs for simultaneous delivery of anti‐inflammatory agents to mustard‐induced skin injury
Author(s) -
Lacey Carl J.,
Wohlman Irene,
Guillon Christophe,
Saxena Jaya,
FianuVelgus Cynthia,
Aponte Erik,
Young Sherri C.,
Heck Diane E.,
Joseph Laurie B.,
Laskin Jeffrey D.,
Heindel Ned D.
Publication year - 2016
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13177
Subject(s) - sulfur mustard , prodrug , inflammation , pharmacology , chemistry , enzyme , medicine , biochemistry , immunology , toxicity , organic chemistry
The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation‐related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug development domain over the last 8 years.