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Personalized and targeted therapy of esophageal squamous cell carcinoma: an update
Author(s) -
Liu Yongjing,
Xiong Zhaohui,
Beasley Andrea,
D'Amico Thomas,
Chen Xiaoxin Luke
Publication year - 2016
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13144
Subject(s) - targeted therapy , lineage (genetic) , esophageal squamous cell carcinoma , medicine , sox2 , cancer research , mechanism (biology) , oncology , disease , basal cell , carcinoma , bioinformatics , biology , cancer , embryonic stem cell , gene , genetics , philosophy , epistemology
Esophageal squamous cell carcinoma (ESCC) is a deadly disease that requires extensive research. In this review, we update recent progress in the research area of targeted therapy for ESCC. SOX2 and its associated proteins (e.g., ΔNP63α), which regulate lineage survival of ESCC cells, are proposed as therapeutic targets. It is believed that targeting the lineage‐survival mechanism may be more effective than targeting other mechanisms. With the advent of a new era of personalized targeted therapy, there is a need to move from the tumor‐centric model into an organismic model.