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Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants
Author(s) -
Malaviya Rama,
Sunil Vasanthi R.,
Venosa Alessandro,
Vayas Kinal N.,
Businaro Rita,
Heck Diane E.,
Laskin Jeffrey D.,
Laskin Debra L.
Publication year - 2016
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13123
Subject(s) - pulmonary injury , inflammation , chemistry , immunology , medicine , microbiology and biotechnology , biology , lung , pulmonary fibrosis
Sulfur mustard (SM) and nitrogen mustard (NM) are cytotoxic alkylating agents that cause severe and progressive injury to the respiratory tract, resulting in significant morbidity and mortality. Evidence suggests that macrophages and the inflammatory mediators they release play roles in both acute and long‐term pulmonary injuries caused by mustards. In this article, we review the pathogenic effects of SM and NM on the respiratory tract and potential inflammatory mechanisms contributing to this activity.