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Endothelial‐to‐hematopoietic transition: Notch‐ing vessels into blood
Author(s) -
Kanz Dirk,
Konantz Martina,
Alghisi Elisa,
North Trista E.,
Lengerke Claudia
Publication year - 2016
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13030
Subject(s) - dorsal aorta , zebrafish , haematopoiesis , biology , microbiology and biotechnology , hematopoietic stem cell , mesonephros , stem cell , notch signaling pathway , regulator , endothelial stem cell , genetics , embryonic stem cell , signal transduction , in vitro , gene
During development, hematopoietic stem cells (HSCs) are formed in a temporally and spatially restricted manner, arising from specialized endothelial cells (ECs) in the ventral wall of the dorsal aorta within the evolutionary conserved aorta–gonad–mesonephros region. Our understanding of the processes regulating the birth of HSCs from ECs has been recently advanced by comprehensive molecular analyses of developing murine hematopoietic cell populations complemented by studies in the zebrafish model, with the latter offering unique advantages for genetic studies and direct in vivo visualization of HSC emergence. Here, we provide a concise review of the current knowledge and recent advances regarding the cellular origin and molecular regulation of HSC development, with particular focus on the process of endothelial‐to‐hematopoietic transition and its primary regulator, the Notch signaling pathway.