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Niche heterogeneity in the bone marrow
Author(s) -
Birbrair Alexander,
Frenette Paul S.
Publication year - 2016
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.13016
Subject(s) - niche , haematopoiesis , bone marrow , biology , stem cell , function (biology) , stem cell niche , hematopoietic stem cell , microbiology and biotechnology , immunology , progenitor cell , ecology
In adult mammals, hematopoietic stem cells (HSCs) are defined by their abilities to self‐renew and to differentiate to form all blood cell lineages. These rare multipotent cells occupy specific locations in the bone marrow (BM) microenvironment. The specific microenvironment regulating HSCs, commonly referred to as the niche, comprises multiple cell types whose exact contributions are under active investigation. Understanding cellular cross talk involving HSCs in the BM microenvironment is of fundamental importance for harnessing therapies against benign and malignant blood diseases. In this review, we summarize and evaluate recent advances in our understanding of niche heterogeneity and its influence on HSC function.