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Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span
Author(s) -
BrownBorg Holly M.
Publication year - 2016
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12971
Subject(s) - longevity , life span , psychological intervention , hormone , methionine , stressor , affect (linguistics) , growth hormone , gerontology , biology , physiology , medicine , endocrinology , psychology , biochemistry , neuroscience , psychiatry , amino acid , communication
Interventions that improve health are often associated with longevity. Reduced growth hormone signaling has been shown to increase life span in mice by over 50%. Similarly, reductions in dietary intake of methionine, in rats and mice, result in life‐span extension. Many factors affect metabolic health, mitochondrial function, and resistance to stressors, each of which influence aging and life span. This paper presents a comparison of these two interventions, as well as the results of a study combining these interventions, to understand potential mechanisms underlying their effectiveness in enhancing healthy aging.