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Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease
Author(s) -
SerranoPuebla Ana,
Boya Patricia
Publication year - 2016
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12966
Subject(s) - programmed cell death , microbiology and biotechnology , autophagy , lysosome , biology , cell , disease , lysosomal storage disease , catabolism , upstream and downstream (dna) , cell physiology , metabolism , apoptosis , upstream (networking) , biochemistry , enzyme , medicine , pathology , computer network , computer science
Recent studies have demonstrated that, in addition to their central role in cellular catabolic reactions, lysosomes are implicated in many cellular processes, including metabolism, membrane repair, and cell death. Lysosomal membrane permeabilization (LMP) has emerged as a pathway by which cell demise is regulated under physiological conditions and contributes to cell death in many pathological situations. Here, we review the latest evidence on LMP‐mediated cell death, the upstream and downstream signals involved, and the role of LMP in the normal physiology of organisms. We also discuss the contributions of lysosomal damage and LMP to the pathogenic features of several disease states, such as lysosomal storage disorders and other neurodegenerative conditions.