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Calcium signaling as a mediator of cell energy demand and a trigger to cell death
Author(s) -
Bhosale Gauri,
Sharpe Jenny A.,
Sundier Stephanie Y.,
Duchen Michael R.
Publication year - 2015
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12885
Subject(s) - microbiology and biotechnology , calcium , calcium signaling , mediator , mitochondrion , signal transduction , programmed cell death , oxidative stress , cell , biology , chemistry , apoptosis , biochemistry , organic chemistry
Calcium signaling is pivotal to a host of physiological pathways. A rise in calcium concentration almost invariably signals an increased cellular energy demand. Consistent with this, calcium signals mediate a number of pathways that together serve to balance energy supply and demand. In pathological states, calcium signals can precipitate mitochondrial injury and cell death, especially when coupled to energy depletion and oxidative or nitrosative stress. This review explores the mechanisms that couple cell signaling pathways to metabolic regulation or to cell death. The significance of these pathways is exemplified by pathological case studies, such as those showing loss of mitochondrial calcium uptake 1 in patients and ischemia/reperfusion injury.