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Alcohol and violence: neuropeptidergic modulation of monoamine systems
Author(s) -
Miczek Klaus A.,
DeBold Joseph F.,
Hwa Lara S.,
Newman Emily L.,
Almeida Rosa M. M.
Publication year - 2015
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12862
Subject(s) - neuroscience , ionotropic effect , monoamine neurotransmitter , dorsal raphe nucleus , metabotropic receptor , psychology , impulsivity , nucleus accumbens , glutamate receptor , poison control , medicine , clinical psychology , serotonergic , dopamine , receptor , serotonin , environmental health
Neurobiological processes underlying the epidemiologically established link between alcohol and several types of social, aggressive, and violent behavior remain poorly understood. Acute low doses of alcohol, as well as withdrawal from long‐term alcohol use, may lead to escalated aggressive behavior in a subset of individuals. An urgent task will be to disentangle the host of interacting genetic and environmental risk factors in individuals who are predisposed to engage in escalated aggressive behavior. The modulation of 5‐hydroxytryptamine impulse flow by gamma‐aminobutyric acid (GABA) and glutamate, acting via distinct ionotropic and metabotropic receptor subtypes in the dorsal raphe nucleus during alcohol consumption, is of critical significance in the suppression and escalation of aggressive behavior. In anticipation and reaction to aggressive behavior, neuropeptides such as corticotropin‐releasing factor, neuropeptide Y, opioid peptides, and vasopressin interact with monoamines, GABA, and glutamate to attenuate and amplify aggressive behavior in alcohol‐consuming individuals. These neuromodulators represent novel molecular targets for intervention that await clinical validation. Intermittent episodes of brief social defeat during aggressive confrontations are sufficient to cause long‐lasting neuroadaptations that can lead to the escalation of alcohol consumption.