Premium
B‐1 phagocytes: the myeloid face of B‐1 cells
Author(s) -
Popi Ana Flavia
Publication year - 2015
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12814
Subject(s) - phagocyte , haematopoiesis , b cell , myeloid , immune system , biology , myeloid cells , immunology , regulatory b cells , antibody , macrophage , microbiology and biotechnology , stem cell , genetics , in vitro
The relationship between malignant B cells and macrophages has long been established. Furthermore, evolutionary studies have demonstrated that B cells from early vertebrates have both phagocytic and antibody production capabilities. In addition to their lymphoid nature, B‐1 cells retain several myeloid characteristics. Various reports have demonstrated that B‐1 cells can differentiate into phagocytes. However, descriptions of B‐1 cells as a novel phagocyte cell member are rarely found in the literature. This review aims to present the available data regarding B‐1 cell–derived phagocytes and also discusses how their existence might be relevant to hematopoiesis and immune responses.