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NF‐κB signaling in B‐1 cell development
Author(s) -
Pedersen Gabriel K.,
Ádori Monika,
Hedestam Gunilla B. Karlsson
Publication year - 2015
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12800
Subject(s) - nf κb , transcription factor , signal transduction , microbiology and biotechnology , nfkb1 , haematopoiesis , b cell , biology , immunology , stem cell , genetics , gene , antibody
NF‐κB transcription factors play essential roles in hematopoiesis. In this review, we summarize the requirements of different components of the NF‐κB pathway for B‐1 cell development and maintenance. The B‐1 cell developmental steps are also reviewed, with particular emphasis on stages where NF‐κB signaling may be critical.