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Antimalarial drug resistance in Africa: key lessons for the future
Author(s) -
TakalaHarrison Shan,
Laufer Miriam K.
Publication year - 2015
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12766
Subject(s) - malaria , drug resistance , chloroquine , artemisinin , drug , sulfadoxine , pyrimethamine , medicine , resistance (ecology) , plasmodium falciparum , intensive care medicine , pharmacology , biology , immunology , ecology , microbiology and biotechnology
Drug‐resistant parasites repeatedly arise as a result of widespread use of antimalarial drugs and have contributed significantly to the failure to control and eradicate malaria throughout the world. In this review, we describe the spread of resistance to chloroquine and sulfadoxine–pyrimethamine, two old drugs that are no longer used owing to high rates of resistance, and examine the effect of the removal of drug pressure on the survival of resistant parasites. Artemisinin‐resistant malaria is now emerging in Southeast Asia in a unique and unexpected pattern. We will review the most recent genomic and clinical data to help predict the behavior of resistance to new antimalarial medications and inform strategies to prevent the spread of drug‐resistant malaria in Africa in the future.