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Angiopoietin‐2: a multifaceted cytokine that functions in both angiogenesis and inflammation
Author(s) -
Scholz Alexander,
Plate Karl H.,
Reiss Yvonne
Publication year - 2015
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12726
Subject(s) - angiogenesis , inflammation , angiopoietin , cytokine , angiopoietin receptor , function (biology) , immunology , signal transduction , downregulation and upregulation , cancer research , biology , microbiology and biotechnology , vascular endothelial growth factor , gene , vegf receptors , genetics
Angiogenesis and inflammation are two highly linked processes. In the last decade, several factors with dual function in both of these major pathways have been identified. This review focuses on angiopoietin‐2 (Ang‐2), an important proangiogenic factor that has more recently been implicated in mediating inflammatory processes as well. Ang‐2 is upregulated in multiple inflammatory diseases and has been implicated in the direct control of inflammation‐related signaling pathways. As a consequence of its multiple roles, designs for therapeutic targeting of Ang‐2 should consider the dual function of this factor in regulating angiogenesis and inflammation.