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Diagnosis and treatment of depression and cognitive impairment in late life
Author(s) -
Morimoto Sarah Shizuko,
Kanellopoulos Dora,
Manning Kevin J.,
Alexopoulos George S.
Publication year - 2015
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12669
Subject(s) - late life depression , dementia , depression (economics) , cognition , context (archaeology) , psychology , cognitive impairment , clinical psychology , psychological intervention , executive functions , antidepressant , executive dysfunction , cognitive remediation therapy , psychiatry , medicine , neuropsychology , disease , anxiety , paleontology , biology , economics , macroeconomics , pathology
Cognitive impairment in late‐life depression is prevalent, disabling, and heterogeneous. Although mild cognitive impairment in depression does not usually progress to dementia, accurate assessment of cognition is vital to prognosis and treatment planning. For example, executive dysfunction often accompanies late‐life depression, influences performance across cognitive domains, and is associated with poor antidepressant treatment outcomes. Here, we review how assessment can capture dysfunction across cognitive domains and discuss cognitive trajectories frequently observed in late‐life depression in the context of the neurobiology of this disorder. We also review the efficacy of a sample of interventions tailored to specific cognitive profiles.