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Mechanism of NLRP3 inflammasome activation
Author(s) -
Sutterwala Fayyaz S.,
Haasken Stefanie,
Cassel Suzanne L.
Publication year - 2014
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12458
Subject(s) - inflammasome , pyroptosis , innate immune system , mechanism (biology) , proinflammatory cytokine , caspase 1 , priming (agriculture) , acquired immune system , microbiology and biotechnology , neuroscience , programmed cell death , aim2 , immunity , immune system , biology , immunology , chemistry , inflammation , apoptosis , genetics , philosophy , botany , germination , epistemology
Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen‐ and damage‐associated molecular patterns into a proinflammatory response. This potent caspase‐1–dependent process is capable of activating the innate immune system, initiating pyroptosis (an inflammatory form of programmed cell death), and shaping adaptive immunity. The NLRP3 inflammasome is the most thoroughly studied of the inflammasome complexes that have been described thus far, perhaps owing to its disparate assortment of agonists. This review highlights our current understanding of the mechanisms of both priming and activation of the NLRP3 inflammasome.