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Radiation‐induced, cell cycle–related gene expression in aging hematopoietic stem cells: enigma of their recovery
Author(s) -
Hirabayashi Yoko
Publication year - 2014
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12401
Subject(s) - fyn , haematopoiesis , stem cell , biology , cell cycle , bone marrow , microbiology and biotechnology , progenitor cell , cancer research , cell , immunology , kinase , genetics , proto oncogene tyrosine protein kinase src
This paper reviews quantitative and qualitative studies conducted to identify changes in the characteristics of hematopoietic stem/progenitor cells (HSCs/HPCs) with or without radiation exposure. The numerical recovery of HSCs/HPCs after radiation exposure is lower than for other types of cells, an effect that may depend on hierarchical ordering of generation age during blood cell differentiation, from primitive HSCs to various differentiated HPCs. Studies are in progress to evaluate gene expression in bone marrow cells and cells in the lineage‐negative, c‐Kit + , stem cell antigen + (LKS) fraction from 21‐month‐old mice, with or without radiation exposure. Preliminary data suggest that cell cycle–related genes, that is, cyclin D1 ( Ccnd1 ), phosphatidylinositol 3 kinase regulatory subunit polypeptide 1 ( PiK3r1 ), and Fyn , are upregulated solely in the LKS fraction from 21‐month‐old mice irradiated at 6 weeks of age, compared with the LKS fraction from age‐matched nonirradiated control mice. Additional studies may provide evidence that the aging phenotype is exaggerated following exposure to ionizing radiation, specifically in the LKS fraction.