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Importance of lipid microdomains, rafts, in absorption, delivery, and biological effects of resveratrol
Author(s) -
Delmas Dominique,
Aires Virginie,
Colin Didier J.,
Limagne Emeric,
Scagliarini Alessandra,
Cotte Alexia K.,
Ghiringhelli François
Publication year - 2013
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12177
Subject(s) - lipid raft , endocytosis , resveratrol , lipid microdomain , microbiology and biotechnology , programmed cell death , chemistry , apoptosis , cell , biology , signal transduction , biochemistry , membrane
The preventive effects of the phytoalexin trans ‐resveratrol toward cancer have been largely described at the cellular and molecular levels in both in vivo and in vitro models; however, its primary targets are still poorly identified. In this review, we show the crucial role of cell membrane microdomains, that is, lipid rafts, not solely in the initiation of the early biochemical events triggered by resveratrol leading to cancer cell death, but also in resveratrol absorption and distribution. Resveratrol accumulates in lipid rafts and is then taken up by cells through raft‐dependent endocytosis. These events allow early activation of kinase pathways and redistribution of cell death receptors within lipid microdomains, events ultimately leading to apoptotic cell death.