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In vivo robotics: the automation of neuroscience and other intact‐system biological fields
Author(s) -
Kodandaramaiah Suhasa B.,
Boyden Edward S.,
Forest Craig R.
Publication year - 2013
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12171
Subject(s) - automation , robotics , neuroscience , artificial intelligence , computer science , cognitive science , robot , biology , human–computer interaction , psychology , engineering , mechanical engineering
Robotic and automation technologies have played a huge role in in vitro biological science, having proved critical for scientific endeavors such as genome sequencing and high‐throughput screening. Robotic and automation strategies are beginning to play a greater role in in vivo and in situ sciences, especially when it comes to the difficult in vivo experiments required for understanding the neural mechanisms of behavior and disease. In this perspective, we discuss the prospects for robotics and automation to influence neuroscientific and intact‐system biology fields. We discuss how robotic innovations might be created to open up new frontiers in basic and applied neuroscience and present a concrete example with our recent automation of in vivo whole‐cell patch clamp electrophysiology of neurons in the living mouse brain.