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Human B‐1 cells take the stage
Author(s) -
Rothstein Thomas L.,
Griffin Daniel O.,
Holodick Nichol E.,
Quach Tam D.,
Kaku Hiroaki
Publication year - 2013
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12137
Subject(s) - b cell , antibody , biology , immunology , b 1 cell , immune system , regulatory b cells , cd40 , autoantibody , microbiology and biotechnology , naive b cell , t cell , antigen presenting cell , cytotoxic t cell , in vitro , genetics
B‐1 cells play critical roles in defending against microbial invasion and in housekeeping removal of cellular debris. B‐1 cells secrete natural antibody and manifest functions that influence T cell expansion and differentiation and in these and other ways differ from conventional B‐2 cells. B‐1 cells were originally studied in mice where they are easily distinguished from B‐2 cells, but their identity in the human system remained poorly defined for many years. Recently, functional criteria for human B‐1 cells were established on the basis of murine findings, and reverse engineering resulted in identification of the phenotypic profile, CD20 + CD27 + CD43 + CD70 − , for B‐1 cells found in both umbilical cord blood and adult peripheral blood. Human B‐1 cells may contribute to multiple disease states through production of autoantibody and stimulation/modulation of T cell activity. Human B‐1 cells could be a rich source of antibodies useful in treating diseases present in elderly populations where natural antibody protection may have eroded. Manipulation of human B‐1 cell numbers and/or activity may be a new avenue for altering T cell function and treating immune dyscrasias.