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The National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress
Author(s) -
Dickler Howard B.,
McCoy J. Philip,
Nussenblatt Robert,
Perl Shira,
Schwartzberg Pamela A.,
Tsang John S.,
Wang Ena,
Young Neil S.
Publication year - 2013
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/nyas.12101
Subject(s) - autoimmunity , psychological intervention , immune system , immunology , modalities , disease , inflammation , human disease , medicine , bioinformatics , computational biology , biology , pathology , social science , psychiatry , sociology
The Center for Human Immunology, Autoimmunity, and Inflammation (CHI) is an exciting initiative of the NIH intramural program begun in 2009. It is uniquely trans‐NIH in support (multiple institutes) and leadership (senior scientists from several institutes who donate their time). Its goal is an in‐depth assessment of the human immune system using high‐throughput multiplex technologies for examination of immune cells and their products, the genome, gene expression, and epigenetic modulation obtained from individuals both before and after interventions, adding information from in‐depth clinical phenotyping, and then applying advanced biostatistical and computer modeling methods for mining these diverse data. The aim is to develop a comprehensive picture of the human “immunome” in health and disease, elucidate common pathogenic pathways in various diseases, identify and validate biomarkers that predict disease progression and responses to new interventions, and identify potential targets for new therapeutic modalities. Challenges, opportunities, and progress are detailed.