Premium
Disruption of plant plasma membrane by Nep1‐like proteins in pathogen–plant interactions
Author(s) -
Pirc Katja,
Albert Isabell,
Nürnberger Thorsten,
Anderluh Gregor
Publication year - 2023
Publication title -
new phytologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.742
H-Index - 244
eISSN - 1469-8137
pISSN - 0028-646X
DOI - 10.1111/nph.18524
Subject(s) - membrane , biology , membrane integrity , microbiology and biotechnology , plant cell , mechanism (biology) , pathogen , botany , chemistry , biochemistry , gene , philosophy , epistemology
Summary Lipid membrane destruction by microbial pore‐forming toxins (PFTs) is a ubiquitous mechanism of damage to animal cells, but is less prominent in plants. Nep1‐like proteins (NLPs) secreted by phytopathogens that cause devastating crop diseases, such as potato late blight, represent the only family of microbial PFTs that effectively damage plant cells by disrupting the integrity of the plant plasma membrane. Recent research has elucidated the molecular mechanism of NLP‐mediated membrane damage, which is unique among microbial PFTs and highly adapted to the plant membrane environment. In this review, we cover recent insight into how NLP cytolysins damage plant membranes and cause cell death.