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Geminivirus C4 antagonizes the HIR1‐mediated hypersensitive response by inhibiting the HIR1 self‐interaction and promoting degradation of the protein
Author(s) -
Mei Yuzhen,
Ma Zhonghua,
Wang Yaqin,
Zhou Xueping
Publication year - 2020
Publication title -
new phytologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.742
H-Index - 244
eISSN - 1469-8137
pISSN - 0028-646X
DOI - 10.1111/nph.16208
Subject(s) - hypersensitive response , downregulation and upregulation , microbiology and biotechnology , protein–protein interaction , degradation (telecommunications) , chemistry , virus , gene , biology , biochemistry , virology , plant disease resistance , telecommunications , computer science
Summary Tomato leaf curl Yunnan virus (TLCYnV)‐encoded C4 protein induces the upregulation of the hypersensitive induced reaction 1 ( HIR1 ) gene but interferes with the HIR1‐mediated hypersensitive response (HR). HIR1 self‐interaction is essential for the HIR1‐induced HR. TLCYnV C4 impairs the HIR1 self‐interaction and concomitantly increases the amount of Leucine‐Rich Repeat protein 1 (LRR1), a modulator of HIR1, which binds to HIR1. LRR1 promotes the degradation of HIR1, compromising the HIR1‐mediated HR. This study provides new insights into the mechanisms employed by a viral protein to counter host resistance through the cooption of the host regulatory system.