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The bifunctional transporter‐receptor IRT 1 at the heart of metal sensing and signalling
Author(s) -
Cointry Virginia,
Vert Grégory
Publication year - 2019
Publication title -
new phytologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.742
H-Index - 244
eISSN - 1469-8137
pISSN - 0028-646X
DOI - 10.1111/nph.15826
Subject(s) - transporter , signalling , microbiology and biotechnology , efflux , regulator , receptor , biology , chemistry , biochemistry , gene
Summary Transporters are at the centre of regulatory modules allowing optimal assimilation, distribution or efflux of substrate molecules. The IRT 1 root metal transporter represents a textbook example in which detailed regulatory networks have been shown to integrate several endogenous and exogenous cues at various levels to regulate its expression and to fine tune iron uptake. Here, we summarise recent advances in the dissection of the transcriptional and posttranslational control of IRT 1 by its various metals substrates and discuss the emerging role of IRT 1 in the direct sensing of non‐iron metals flowing through IRT 1 to drive its degradation. We propose that transporters that also act as receptors are likely to be a common theme in the regulation of nutrient transport by sensing local nutrient concentrations.