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A core function of EDS1 with PAD4 is to protect the salicylic acid defense sector in Arabidopsis immunity
Author(s) -
Cui Haitao,
Gobbato Enrico,
Kracher Barbara,
Qiu Jingde,
Bautor Jaqueline,
Parker Jane E.
Publication year - 2017
Publication title -
new phytologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.742
H-Index - 244
eISSN - 1469-8137
pISSN - 0028-646X
DOI - 10.1111/nph.14302
Subject(s) - arabidopsis , biology , effector , immunity , innate immune system , microbiology and biotechnology , plant immunity , plant disease resistance , salicylic acid , phytoalexin , transcriptome , signal transduction , gene , plant defense against herbivory , immune system , mutant , gene expression , genetics , biochemistry , resveratrol
Summary Plant defenses induced by salicylic acid (SA) are vital for resistance against biotrophic pathogens. In basal and receptor‐triggered immunity, SA accumulation is promoted by Enhanced Disease Susceptibility1 with its co‐regulator Phytoalexin Deficient4 (EDS1/PAD4). Current models position EDS1/PAD4 upstream of SA but their functional relationship remains unclear. In a genetic and transcriptomic analysis of Arabidopsis autoimmunity caused by constitutive or conditional EDS1/PAD4 overexpression, intrinsic EDS1/PAD4 signaling properties and their relation to SA were uncovered. A core EDS1/PAD4 pathway works in parallel with SA in basal and effector‐triggered bacterial immunity. It protects against disabled SA‐regulated gene expression and pathogen resistance, and is distinct from a known SA‐compensatory route involving MAPK signaling. Results help to explain previously identified EDS1/PAD4 regulated SA‐dependent and SA‐independent gene expression sectors. Plants have evolved an alternative route for preserving SA‐regulated defenses against pathogen or genetic perturbations. In a proposed signaling framework, EDS1 with PAD4, besides promoting SA biosynthesis, maintains important SA‐related resistance programs, thereby increasing robustness of the innate immune system.