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Comparative genomic de‐convolution of the cotton genome revealed a decaploid ancestor and widespread chromosomal fractionation
Author(s) -
Wang Xiyin,
Guo Hui,
Wang Jinpeng,
Lei Tianyu,
Liu Tao,
Wang Zhenyi,
Li Yuxian,
Lee TaeHo,
Li Jingping,
Tang Haibao,
Jin Dianchuan,
Paterson Andrew H.
Publication year - 2016
Publication title -
new phytologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.742
H-Index - 244
eISSN - 1469-8137
pISSN - 0028-646X
DOI - 10.1111/nph.13689
Subject(s) - genome , biology , gene , comparative genomics , most recent common ancestor , ancestor , genetics , evolutionary biology , homology (biology) , ploidy , genome evolution , chromosome , lineage (genetic) , gene family , gene duplication , genomics , gene density , history , archaeology
Summary The ‘apparently’ simple genomes of many angiosperms mask complex evolutionary histories. The reference genome sequence for cotton ( Gossypium spp.) revealed a ploidy change of a complexity unprecedented to date, indeed that could not be distinguished as to its exact dosage. Herein, by developing several comparative, computational and statistical approaches, we revealed a 5× multiplication in the cotton lineage of an ancestral genome common to cotton and cacao, and proposed evolutionary models to show how such a decaploid ancestor formed. The c . 70% gene loss necessary to bring the ancestral decaploid to its current gene count appears to fit an approximate geometrical model; that is, although many genes may be lost by single‐gene deletion events, some may be lost in groups of consecutive genes. Gene loss following cotton decaploidy has largely just reduced gene copy numbers of some homologous groups. We designed a novel approach to deconvolute layers of chromosome homology, providing definitive information on gene orthology and paralogy across broad evolutionary distances, both of fundamental value and serving as an important platform to support further studies in and beyond cotton and genomics communities.