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Postoperative ileus—An ongoing conundrum
Author(s) -
Wattchow David,
Heitmann Paul,
Smolilo David,
Spencer Nick J.,
Parker Dominic,
Hibberd Timothy,
Brookes Simon S. J.,
Dinning Phil G.,
Costa Marcello
Publication year - 2021
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.14046
Subject(s) - ileus , postoperative ileus , intensive care medicine , medicine , neuroscience , psychology , surgery
Background Postoperative ileus is common and is a major clinical problem. It has been widely studied in patients and in experimental models in laboratory animals. A wide variety of treatments have been tested to prevent or modify the course of this disorder. Purpose This review draws together information on animal studies of ileus with studies on human patients. It summarizes some of the conceptual advances made in understanding the mechanisms that underlie paralytic ileus. The treatments that have been tested in human subjects (both pharmacological and non‐pharmacological) and their efficacy are summarized and graded consistent with current clinical guidelines. The review is not intended to provide a comprehensive overview of ileus, but rather a general understanding of the major clinical problems associated with it, how animal models have been useful to elucidate key mechanisms and, finally, some perspectives from both scientists and clinicians as to how we may move forward with this debilitating yet common condition.