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Severe gastroparesis is associated with an increased incidence of slow‐transit constipation as measured by wireless motility capsule
Author(s) -
Radetic Mark,
Kamal Afrin,
Rouphael Carol,
Kou Lei,
Lyu Ruishen,
Cline Michael
Publication year - 2021
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.14045
Subject(s) - gastroparesis , medicine , gastroenterology , constipation , gastric emptying , stomach
Background Dysmotility in one region of the gastrointestinal tract has been found to predispose patients to developing motility disorders in other gastrointestinal segments. However, few studies have evaluated the relationship between gastroparesis and constipation. Methods Retrospective review of 224 patients who completed 4‐hour, solid‐phase gastric emptying scintigraphy (GES), and wireless motility capsule (WMC) testing to evaluate for gastroparesis and slow‐transit constipation, respectively. When available, anorectal manometry data were reviewed to evaluate for dyssynergic defecation. Patients were divided into two groups based on the results of the GES: 101 patients with normal gastric emptying and 123 patients with gastroparesis (stratified by severity). Differences in constipation rates were compared between the groups. Key results Slow‐transit constipation was more common in the gastroparesis group, but statistical significance was not reached (42.3% vs 34.7%, p = 0.304). Univariate logistical regression analysis found no association between slow‐transit constipation and gastroparesis (OR 1.38, 95% CI 0.80‐2.38, p = 0.245) nor dyssynergic defecation and gastroparesis (OR 0.88, 95% CI 0.29‐2.70, p = 0.822). However, when stratifying gastroparesis based on severity, slow‐transit constipation was found to be associated with severe gastroparesis (OR 2.45, 95% CI 1.20‐5.00, p = 0.014). This association was strengthened with the exclusion of patients with diabetes mellitus (OR 3.5, 95% CI 1.39‐8.83, p = 0.008) ‐ a potential confounder. Conclusions & Inferences Patients with severe gastroparesis (>35% gastric retention at the 4‐hour mark on solid‐phase GES) have an increased likelihood of having underlying slow‐transit constipation. Dyssynergic defecation does not appear to be associated with gastroparesis (of any severity).