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Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal‐physiological function and against loperamide‐induced constipation coupled to oxidative stress and inflammation in rats
Author(s) -
Hajji Najla,
Wannes Dalanda,
Jabri MohamedAmine,
Rtibi Kais,
Tounsi Haifa,
Abdellaoui Afifa,
Sebai Hichem
Publication year - 2020
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.13858
Subject(s) - laxative , loperamide , constipation , gastric emptying , medicine , oxidative stress , gastroenterology , irritable bowel syndrome , defecation , pharmacology , gastrointestinal disorder , traditional medicine , stomach , diarrhea
Background Chronic constipation is a gastrointestinal functional disorder which affects patient quality of life. Therefore, many studies were oriented to search herbal laxative agents. In this study, we investigated the effect of Globularia alypum L. leaves aqueous extract (GAAE) against loperamide (LOP)‐produced constipation. Methods Animals were given LOP (3 mg/kg, b.w ., i.p. ) and GAAE (100, 200, and 400 mg/kg, b.w ., p.o .) or yohimbine (2 mg/kg, b.w., i.p. ), simultaneously, for 1 week. Gastric‐emptying test and intestinal transit were determined. Colon histology was examined, and oxidative status was evaluated using biochemical‐colorimetric methods. Key Results GAAE ameliorates significantly gastric emptying (64% to 76.5%) and intestinal transit (66.65% to 84.73%). LOP negatively influenced defecation parameters and generated a stress situation. GAAE administration in contrast ameliorated those parameters and re‐established oxidative balance. Conclusion GAAE showed a modest action against oxidative stress and decreased LOP effect and thereby can be considered a pharmacological agent in constipation.