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New parameter for quantifying bolus transit with high‐resolution impedance manometry: A comparison with simultaneous esophagogram
Author(s) -
Gong Eun Jeong,
Choi Kyungmin,
Jung Kee Wook,
Pandolfino John. E.,
Kim Do Yeon,
Yoon In Ja,
Seo So Young,
Koo Hyun Sook,
Na Hee Kyong,
Ahn Ji Yong,
Lee Jeong Hoon,
Choi Kee Don,
Kim Do Hoon,
Song Ho June,
Lee Gin Hyug,
Jung HwoonYong,
Myung SeungJae,
Kim Nayoung,
Joo Segyeong
Publication year - 2020
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/nmo.13847
Subject(s) - medicine , bolus (digestion) , intraclass correlation , esophagus , residual volume , nuclear medicine , lung volumes , clinical psychology , lung , psychometrics
Background Esophageal bolus transit can be assessed using esophagogram or high‐resolution impedance manometry (HRIM). The three‐dimensional volume of inverted impedance (VII) has been developed to quantify the residual bolus between each swallow through spatiotemporal analysis. However, this novel metric has not been validated against simultaneous esophagogram. Methods A total of nine healthy volunteers (Seven males, aged 19‐45 years) were prospectively evaluated with HRIM and barium esophagogram. In addition, 21 symptomatic patients (12 males, aged 20‐85 years) without major motility disorder were also included. The VII was estimated from HRIM data using MATLAB program and was compared with residual bolus volume in the esophagus estimated from simultaneous esophagogram. Key results A total of 80 swallows (24 in controls and 56 in patients) were analyzed. Results from the VII method were concordant with the bolus transit pattern estimated from the esophagogram in 91.3% (73/80) of swallows. The correlation between quantitative data from VII and the volume of residual bolus estimated from esophagogram was strong in both groups with a Pearson's correlation coefficient of 0.805 for healthy volunteers and 0.730 for symptomatic patients. The intraclass correlation coefficient of VII between the three swallows within a subject was 0.901 in healthy subjects and 0.705 in patients, indicating a modest reliability of this method. Conclusions and inferences The newly developed VII method is a reliable method in assessing residual bolus volume in the esophagus based on comparison with bolus volume estimated from simultaneous esophagogram.